Round-robin studies for standardized proteomic workflows of relevant clinical specimens

The CLINSPECT-M consortium initiated a round-robin study among its six proteomic laboratories aimed to enhance the integration of mass spectrometry (MS)-based proteomics into medical research by establishing standardized workflows for clinical specimens. The team led by Oliver Kardell and Stefanie Hauck conducted two rounds of collaborative testing, focusing on sample preparation and MS setups. Using plasma and cerebrospinal fluid, each lab initially applied its best practices, followed by a transparent exchange of protocols. After refining methods, the labs retested the samples. Comparing the two rounds revealed improved performance, showcasing the value of sharing expertise for practical enhancements. This emphasizes the need for standardized protocols in MS-based proteomics for more reliable and meaningful clinical applications.
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